溯经典之源，探交叉之本。与我们共赴物理生物学经典读书会（Physical Biology Journal Club），回到伟大思想诞生的现场！
Topic: Adaptation in Control Terms: From Signal Amplification to Robust Perfect Adaptation
Speaker: Yihao Lin (林奕豪), PhD student, Westlake University
Time: 16:00-17:30, Thursday, June 18, 2026
Venue: E14-326, Research Center, Westlake University
Reference:
[1] Koshland, D. E. Jr., Goldbeter, A., & Stock, J. B. (1982). Amplification and adaptation in regulatory and sensory systems. Science, 217(4556), 220–225. https://doi.org/10.1126/science.7089556
[2] Barkai, N., & Leibler, S. (1997). Robustness in simple biochemical networks. Nature, 387(6636), 913–917. https://doi.org/10.1038/43199
[3] Yi, T. M., Huang, Y., Simon, M. I., & Doyle, J. (2000). Robust perfect adaptation in bacterial chemotaxis through integral feedback control. Proceedings of the National Academy of Sciences, 97(9), 4649–4653. https://doi.org/10.1073/pnas.97.9.4649
Key Words: Adaptation; amplification; feedback control; robustness; bacterial chemotaxis; biochemical networks; integral feedback.
Abstract:
This journal club will continue our previous discussion of "proportional control with an adjustable set point" in thermoregulation, and will further examine how ideas from control theory entered the study of cellular regulation and sensory systems. Centering on the classic 1982 paper by Koshland, Goldbeter, and Stock, *Amplification and Adaptation in Regulatory and Sensory Systems*, we will discuss why biological systems often need to achieve signal amplification and adaptation at the same time. On the one hand, weak inputs must be amplified into detectable outputs; on the other hand, persistent stimuli require the system to recalibrate itself and avoid long-term saturation.
Building on this discussion, we will briefly introduce Barkai and Leibler's 1997 work on robust adaptation in bacterial chemotaxis, showing how adaptation was transformed from a general principle of biological regulation into a concrete problem of biochemical network architecture. Finally, we will connect this line of thought to the 2000 PNAS paper by Yi, Huang, Simon, and Doyle, which interpreted robust perfect adaptation in bacterial chemotaxis as a form of integral feedback control. Through these three papers, this talk aims to trace a conceptual path from physiological homeostasis and cellular adaptation to modern biological control theory.
读书会简介：物理生物学读书会由西湖大学交叉科学中心（CIS）师生共同发起，每周四在轻松自由的氛围中，深入研读物理生物学领域的经典文献，通过追本溯源，激发思想碰撞，促进跨学科交流与合作。
发起人：钱紘，徐小婵
主讲人：以博士后和博士生为核心，全员开放！我们热忱欢迎每一位希望分享的主讲人。
参与成员：欢迎全校所有对物理生物学等交叉领域有浓厚兴趣的师生加入。
地点：科研中心 E14-326 会议室
形式：读书会每周聚焦物理生物学领域的一篇经典论文或书籍章节，通过主讲人领读与集体讨论，理解相关领域的核心概念、理论与模型，系统梳理该领域的基础知识、核心问题与研究范式。
Overview: The Physical Biology Journal Club is a weekly Friday lunchtime event hosted by the faculty and students of the Center for Interdisciplinary Studies (CIS). Our goal is to help everyone learn about how key concepts and groundbreaking discoveries have shaped and inspired the entire research fields. Through lively, in-depth discussion of classic physical biology papers and books, we explore the history, foundational principles, research methodologies, and the remarkable stories of the scientists behind them. Join us to connect with the roots of physical biology and spark ideas in a welcoming environment.
Organizers: Hong Qian, Xiaochan Xu
Speaker: Led by postdocs & PhDs, and everyone can be a host!
Audience: All with a strong interest in physical biology are warmly welcomed.
Venue: E14-326, Research Center, Westlake University
Contact Information
Ms. Jin Liang (梁金), liangjin@westlake.edu.cn, Center for Interdisciplinary Studies (CIS)
Ms. Shujie Du (杜舒节), dushujie@westlake.edu.cn, Center for Interdisciplinary Studies (CIS)
