溯经典之源，探交叉之本。每周四下午，与我们共赴物理生物学经典读书会（Physical Biology Journal Club），回到伟大思想诞生的现场！
Topic: The MWC Model: Structural and Thermodynamic Foundations of Allosteric Transitions
Speaker:Xiaowen Zhang (张潇文), PhD student of the Center for Interdisciplinary Studies (CIS), Westlake University
Reference: Monod J, Wyman J, Changeux JP. On the Nature of Allosteric Transitions: A Plausible Model. Journal of Molecular Biology (1965) 12:88–118.
Key Words: Allostery, MWC model, Cooperativity, Conformational equilibrium, Isologous association, Hill coefficient
Time:16:00-17:30, Thursday, March 12 & 19, 2026
Venue: E5-120, School of Science, Westlake University
Abstract: This landmark paper introduces the Monod–Wyman–Changeux (MWC) model, providing a structural and thermodynamic framework for understanding allosteric regulation in oligomeric proteins. The authors propose that proteins exist in an equilibrium between distinct conformational states and that ligand binding shifts this equilibrium in a concerted manner. By integrating symmetry considerations with statistical thermodynamics, the model explains the emergence of cooperative, sigmoidal binding behavior without invoking direct site–site interaction. The work establishes a foundational paradigm for interpreting allosteric transitions in biological macromolecules.
读书会简介：物理生物学读书会由西湖大学交叉科学中心（CIS）师生共同发起，每周四下午在轻松自由的氛围中，深入研读物理生物学领域的经典文献，通过追本溯源，激发思想碰撞，促进跨学科交流与合作。
发起人：钱紘，徐小婵
主讲人：以博士后和博士生为核心，全员开放！我们热忱欢迎每一位希望分享的主讲人。
参与成员：欢迎全校所有对物理生物学等交叉领域有浓厚兴趣的师生加入。
时间：周四 16:00-17:30
地点：西湖大学理学楼，E5-120会议室
形式：读书会每周聚焦物理生物学领域的一篇经典论文或书籍章节，通过主讲人领读与集体讨论，理解相关领域的核心概念、理论与模型，系统梳理该领域的基础知识、核心问题与研究范式。
Overview: The Physical Biology Journal Club is a weekly Friday lunchtime event hosted by the faculty and students of the Center for Interdisciplinary Studies (CIS). Our goal is to help everyone learn about how key concepts and groundbreaking discoveries have shaped and inspired the entire research fields. Through lively, in-depth discussion of classic physical biology papers and books, we explore the history, foundational principles, research methodologies, and the remarkable stories of the scientists behind them. Join us to connect with the roots of physical biology and spark ideas in a welcoming environment.
Organizers: Hong Qian, Xiaochan Xu
Speaker: Led by postdocs & PhDs, and everyone can be a host!
Audience: All with a strong interest in physical biology are warmly welcomed.
Time: Every Thursday, 16:00-17:30
Venue: E5-120, School of Science, Westlake University
Contact Information
Ms. Jin Liang (梁金), liangjin@westlake.edu.cn, Center for Interdisciplinary Studies (CIS)
