Hanqing Guo-Center For Interdisciplinary Studies

People

Faculty

Hanqing Guo,Ph.D.

▎Biology Website：

▎Embryogenesis and Cell Biology LabEmail：guohanqing12@westlake.edu.cn

Biography

Dr. Hanqing Guo received her bachelor's degree from both Sichuan University and the University of Minnesota-Twin Cities in 2017. She then went to Dartmouth College for her Ph.D. After completing her Ph.D. in 2022, she pursued postdoctoral research at Dartmouth, where she continued her work on exploring the morphogenetic events during embryogenesis using an interdisciplinary approach combining genetics, cell biology, microscopy, and biophysics. Dr. Guo joined Westlake University in 2023 as a Westlake Fellow.

Research

Left-right asymmetry is an important developmental pattern that directs the position and/or twisting of different organs during embryonic development, including the heart, liver, and guts. Failure to establish a correct left-right asymmetry leads to randomized or reversed organ position during embryogenesis, which may result in diseases or abnormalities related to the mispositioned organs or even congenital disabilities under severe conditions. The lab will dissect the mechanisms regulating left-right asymmetry during embryogenesis using Drosophila as the model system and an interdisciplinary approach combining genetics, cell biology, optogenetics, biophysics, and live imaging. Our research interests involve but are not limited to the following topics: 1. Determine how left-right asymmetry establishes during the hindgut dextral rotation process. 2. Investigating how cell chirality influences organ morphogenesis. 3. Exploring the sinistral regulatory pathway during Drosophila embryo development.

Representative Publications **(*Co-corresponding author)**

1. Guo, H.*, Swan, M., He, B.* (2023). Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos. J. Vis. Exp. (194), e65314, doi:10.3791/65314.

2. Guo, H., Swan, M., & He, B. (2022). Optogenetic inhibition of actomyosin reveals mechanical bistability of the mesoderm epithelium during Drosophila mesoderm invagination. eLife, 11, e69082. https://doi.org/10.7554/eLife.69082

3. Guo, H., Huang, S., & He, B. (2022). Evidence for a role of the lateral ectoderm in Drosophila mesoderm invagination. Front. Cell Dev. Biol., https://www.frontiersin.org/article/10.3389/fcell.2022.867438

4. Guo, H., Swan, M., & He, B. (2023). An optogenetic tool to inhibit RhoA in Drosophila embryos. STAR Protocols, 4(1), 101972. https://doi.org/10.1016/J.XPRO.2022.101972

Contact Us

Email: guohanqing12@westlake.edu.cn